'I-28Sfuuy-WR10okMSia3VYeZTm2RHA2LZDel59TlF8' name='google-site-verification'/>www ghs.google.com 6dseurqgapmn gv-v6egtfduggmq3k.dv.googlehosted.com Autismwarriormama: September 2015

Living with Autism

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September 14, 2015

Does Vitamin B-6 dysfunction play a role in autism, epilepsy and self-injurious behavior?

Award Winning Non-Fiction Blogs - BlogCatalog Blog DirectoryAnalysis and Facts:

The majority of vitamin B6 dependent seizures appear from a deficiency in enzyme a-aminoadipic semialdehyde dehydrogenase.

This appears to cause a depletion of B6, pyridoxal phosphate, the active form of B6.

Clinical features may include chronic breakthrough seizures, self-injurious behavior in autistic patients.

Diagnostic testing to help illuminate pathology of SIB and EPILEPSY in autistic patients may include: Pyridoxine trial. Plasma and cerebrospinal fluid pipecolic acid. Urine a-aminoadipic semialdehyde. ALDH7A1 sequencing.

The disorder is rare.

Linked to intractable seizures in patients with autism and self-injurious behavior.

Disorder basically inhibits binding of B6 to glutamic acid, which is needed for GABA biosynthesis.

Source: (Journal of Child Neurology 2000: 15, 763-765)

I lost faith in a lot of autism research studies, but this is an area where I strongly believe the most hope has been offered in many years of "autism research".

No doubt: MORE FUNDING needed for researchers studying the link between metabolic and mitochrondrial issues in autism, epilepsy and aberrant behaviors--- is desperately needed.

Kim Oakley